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The Promise of Factor XI Inhi…ention in Atrial Fibrillation

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The Promise of Factor XI Inhibition for Stroke Prevention in Atrial Fibrillation
Christian T. Ruff, MD, MPH - 03/11/2024
person_outlineReginald Jolicoeur
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    The Promise of Factor XI Inhibition for Stroke Prevention in…
    0:03
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    Learning Objectives
    2:00
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    Epidemic of AF
    2:36
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    Management of AF
    2:54
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    Stroke Prevention in AF Warfarin vs. Placebo
    4:54
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    DOACs
    6:09
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    Stroke Prevention in AF DOACs vs. Warfarin
    7:03
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    DOACs Safer than VKAs but Bleeding Still a Problem
    8:03
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    Failure to Treat Patients with AF Despite Advance of DOAC…
    8:36
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    ELDERCARE -AF
    9:12
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    Factor XI Inhibition
    10:03
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    Patients with Inherited FXI Deficiency Have Low Rates of…
    12:15
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    Strategies to Target Factor XI
    13:18
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    Multiple approaches to Factor Xl Inhibition: Mechanistic…
    13:45
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    Clinical Trials to Date
    15:00
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    FXI VTE Trials - Superior Efficacy vs. LMWH Without…
    16:30
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    PACIFIC -AF
    18:03
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    PACIFIC -AF Bleeding
    18:30
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    PACIFIC -AF Effiacy
    19:00
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    Abelacimab for Prevention of Venous Thromboembolism
    19:39
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    Trial Design
    20:03
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    DMC Recommendation
    20:39
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    Baseline Characteristics
    21:15
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    Primary Endpoint
    22:45
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    Bleeding Endpoints
    23:06
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    Exploratory Endpoints
    23:48
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    Factor XI Phase 3 Trials
    24:39
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    Ongoing Phase 3 Trial of Abelacimab in AF
    25:18
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    Apixaban 5 mg BID (2.5 mg per label)
    26:12
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    Phase 3 OCEANIC -AF Trial in High -risk Patients with AF
    26:33
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    News Release: November 19, 2023
    26:51
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    Stroke Risk in Anticoagulated Patients
    28:42
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    Potency of FXI Inhibition: Asundexian
    31:57
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    What Should We Expect From FXI Inhibitors?
    34:18
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