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Symposium on Resolution of In…ation in Medicine and Surgery

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Symposium on Resolution of Inflammation in Medicine and Surgery
Bornstein Family Amphitheater
Session III
Thursday, February 1
person_outlineReginald Jolicoeur
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    Symposium on Resolution of Inflammation in Medicine and…
    0:06
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    Immunonutrition and/or Pharmaconutrition: SPMs in Surgery…
    4:39
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    Sorting out a working definition we can all agree upon
    5:30
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    Physiological Response to Surgery
    6:12
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    Is modulation of inflammation a laudable goal in surgery and…
    7:33
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    What happened here? wrong nutrient ? wrong timing ? wrong…
    9:03
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    STRONG
    10:27
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    What about metabolic modulating formulations
    11:09
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    fact or fantasy
    11:21
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    • 21 studies, 2005 patients GI malignancies
    12:12
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    Pre-op metabolic manipulation improving outcome
    12:51
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    Relative Range of Inflammatory Effects from Different Lipid…
    13:18
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    Now mechanisms Drs Chiang, Serhan and others have elucidated…
    13:48
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    Will SPMs make a difference
    14:27
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    Activity while hospitalized
    15:30
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    Omega -3 group lost less muscle (quadriceps) during…
    16:12
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    RCTs show omega -3s promote lean mass and muscle mass
    17:12
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    Amino acids
    18:27
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    Resolvin D1 supports skeletal myofiber regeneration via…
    19:03
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    Muscle regeneration
    19:30
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    SPMs — as the downstream metabolites of DHA/EPA have…
    20:24
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    Impact of RvD1 on Progression of Liver Injury or Disease
    20:42
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    Resolvin DI given intraperitoneal for 5 days Resolvin El…
    21:03
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    SPMs: Stroke, TBI, CNS Hemorrhage, Post-op Cognitive Decline
    21:27
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    SPMs and multiple benefits in realm of pain control
    23:45
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    SPMs in Pain models
    24:15
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    Specialized pro-resolving mediators: biosynthesis and…
    24:33
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    Major anti -microbial functions of SPMs, both direct and…
    24:57
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    What about viral infections
    26:21
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    Viral Infections: functions of SPMs
    26:42
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    Resolvins suppress tumor growth and enhance cancer therapy
    26:51
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    What about cancer surgery and SPMs
    27:27
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    Specialized Pro -Resolving Mediators Mitigate Cancer-Related…
    29:03
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    Utility of the Specialized Pro-Resolving Mediators as…
    29:36
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    Can oral intake of Fish Oils or SPMs alter to a clinically…
    29:51
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    Enriched Marine Oil Supplements Increase Peripheral Blood…
    30:30
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    What about IVLE options for lipid delivery
    30:54
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    What is the evidence that SPM's have a potential to be…
    32:36
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    What is the evidence that animal models have shown to be…
    33:12
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    Key Take Home Messages
    33:54
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    Aspirin -Triggered Resolvins and Lipoxins Clearing Infection
    35:45
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    Sepsis and septic shock: a global health priority
    36:57
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    Fate of emigrated neutrophils
    40:00
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    Phagocytosis-induced neutrophil apoptosis and efferocytosis
    41:39
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    RvE1 enhances PICD: Activation of the ROS-caspase-8 axis
    43:00
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    Resolvin El enhances resolution of E. coli pneumonia
    43:54
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    Resolvin El attenuates acute lung injury and prolongs…
    45:15
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    Mechanisms for the pro-apoptotic actions of in human…
    45:45
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    Transfer of septic plasma to neutrophils from healthy donors…
    47:57
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    TLR9 activation impairs neutrophil phagocytosis and PICD
    49:12
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    CpG DNA prolongs ARDS in mice
    51:33
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    Specialized Anti-inflammatory and Pro-resolution Lipid…
    53:06
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    Ligation of ALX/FPR2 with 15-epi-LXA4 or restores impaired…
    53:51
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    and 17-epi-RvD1 facilitate bacterial clearance and enhance…
    55:48
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    facilitates resolution of ARDS in mice
    57:12
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    Neutrophil-macrophage crosstalk: phenotype conversion to M
    57:51
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    macrophages release
    58:33
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    facilitates bacterial clearance and resolution of ARDS in…
    59:36
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    induces formation of 15-epi-LXA4 and RvD1
    1:00:45
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    Impact of neutralizing endogenous
    1:01:18
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    ALX/FPR2 blockade impairs IFN-13-facilitated bacterial…
    1:02:03
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    blockade impairs IFN-13-mediated resolution
    1:03:27
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    promotes resolution of inflammation in lymphedema by…
    1:05:33
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    restores impaired phagocytosis in human neutrophils…
    1:06:06
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    Summary
    1:06:45
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    Acknowledgements
    1:08:30
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    SPMs in Neuroinflammatory and neurodegenerative diseases
    1:11:45
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    INFLAMMATION
    1:12:39
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    The immune system and the brain: Help or Harm?
    1:13:12
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    Resolution of neuroinflammation: existing dogma vs paradigm…
    1:14:33
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    Impairment and dysfunction of neuro-immune interfaces…
    1:15:39
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    Uncontrolled inflammation/Failed resolution A feature of…
    1:16:21
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    SPM receptors
    1:16:45
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    Specialized Pro-resolving Lipid Mediators and Glial Cells:…
    1:17:09
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    OUTLINE
    1:17:21
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    Specialized pro-resolving lipid mediators are differentially…
    1:18:21
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    Parkinson's Disease
    1:22:33
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    Cell-Type -Specific Gene Regulatory Networks of Pro…
    1:25:18
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    Integrative approach to identify Inflammation/Resolution…
    1:26:18
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    Plasma PGs and RvD1 correlate with motor disability in Stage…
    1:30:30
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    SPM receptors are induced in early PD and reduced along…
    1:32:45
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    SPM enzymes are reduced along disease progression in B…
    1:34:21
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    SPM receptors are induced in early PD in B lymphocytes
    1:34:36
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    SPM enzymes are differentially expressed along disease…
    1:35:00
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    Inflammation -Resolution is altered in CSF of PD patients
    1:35:39
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    Resolution of inflammation in Multiple sclerosis: from bench…
    1:42:09
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    ...Unresolved issues
    1:45:00
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    C.E L S I
    1:46:45
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    RESEARCH
    1:49:06
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    Resolvins and SPM in Pain
    1:49:21
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    SPM signaling in neurons, macrophages, and glial cells
    1:49:51
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    Inflammation and Pain
    1:50:21
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    Non -neuronal Cells in Inflammation and Pain
    1:52:09
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    SPMs and resolution of inflammation
    1:53:24
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    Resolvins potently inhibits inflammatory pain
    1:53:36
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    RvE1 inhibits inflammation and neuroinflammation
    1:54:27
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    RvE1 inhibits TRPV1 signaling in DRG and spinal cord neurons…
    1:55:27
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    SPMs are potent endogenous inhibitors of TRPV1 and TRPA1
    1:56:57
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    Vagus nerve and auricular stimulation for inflammation…
    1:58:06
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    Auricular stimulation regulates inflammation and sepsis via…
    1:58:33
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    RvD2 and auri-stim protect against LPS-induced pain and…
    2:00:09
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    Auricular stimulation and RvD2 regulates microglial reaction…
    2:00:51
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    Specialized Pro-Resolving Mediators (SPMs) as Resolution…
    2:01:15
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    SPM receptors and signaling
    2:02:36
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    GPR37 is a possible receptor for NPD1 in macrophages
    2:02:57
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    Reversal of neuropathic pain by NPD1 but not DHA
    2:03:42
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    NPD1 induces macrophage phagocytosis via GPR37
    2:04:54
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    nature
    2:05:48
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    GPR37 protects against sepsis and infection -induced pain
    2:07:30
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    mTBI is induced by closed head injury
    2:07:54
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    NPD1 prevents the development of mechanical pain after mTBI
    2:08:42
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    NPD1 protects against motor and cognitive deficits after…
    2:09:27
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    Demyelination in sensory cortex and hippocampus after mTBI
    2:10:24
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    NPD1 can normalize TBI-induced transcriptional changes
    2:10:51
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    NPD1 can normalize TBI-induced down-regulation of GPR37
    2:12:27
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    GPR37 is required for NPD1's analgesic effects in mice with
    2:13:06
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    Maresin 1 (MaR1) interacts with
    2:14:09
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    identifies satellite glial cells in the DRG
    2:14:33
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    induces K+ signaling in SGCs via
    2:15:30
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    MaR1 reduces neuropathic pain after DPN and CIPN via
    2:16:24
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    Working hypothesis: MaR1/GPR37L1 axis regulates K+ signaling…
    2:16:45
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    alleviates acute and chronic itch
    2:17:33
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    Protectin DX (PDX), 10(S), 17(S) DiHDHA inhibits surgery…
    2:18:27
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    Neuroimmune Modulation for Pain Resolution
    2:19:24
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    Center for Translational Pain Medicine (CTPM)…
    2:20:18
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    a Brigham and Women's
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    aBrigham
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    a Brigham and
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    3:00:45
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